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Expert Discussion - ViroChannel

For more than 20 years, the Clinique médicale l’Actuel, under the medical direction of Dr. Réjean Thomas, has been bringing together healthcare professionals, with a focus in virology, to learn from guest experts and discuss the most relevant clinical practice challenges facing them today.

Nuc-Sparing Regimens & Aging with HIV

with Dr. Benoît Trottier and Dr. Andrew Zolopa


Nuc-Sparing Regimens & Aging with HIV


Whereas decades ago, HIV infection was seen as a death sentence, these days more and more individuals are living and aging with HIV.

In this program, Drs. Andrew Zolopa and Benoît Trottier discuss the challenges of providing long term antiretroviral therapy for individuals living with HIV, focusing on some of the safety issues associated with extended use of the currently recommended regimens and exploring the potential benefits of nuc-sparing regimens for long-term treatment.

This activity is supported by
an educational grant from:

Abbott Virology



  • Use of NRTIs and their risks
  • Whether premature aging is actually a function of HIV infection and treatment or related to other health and lifestyle concerns in infected patients
  • The lack of research on medication dosing for women and older adults
  • NRTIs (specifically mitochondrial toxicity and telomere shortening) and their long term health problems associated with extended use such as organ damage, frailty, and neurocognitive issues
  • Whether novel treatment regimens that do not contain these drugs (nuc-sparing regimens) might be able to effectively control HIV while reducing side-effects
Benoît Trottier

Benoît Trottier


Medical Director of Research
Clinique médicale l’Actuel:
Centre of Excellence HIV–STI–Hepatitis
Affiliated with the Centre hospitalier de l’Université de Montréal (CHUM)
Québec, Canada

Andrew Zolopa, MD

Andrew Zolopa, MD


Professor of Medicine
Stanford University
School of Medicine
Palo Alto, California, USA


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ViroChannel has a conflict of interest policy that requires faculty to disclose relevant financial relationships related to the content of their presentations/materials. Any potential conflicts are resolved so that presentations are evidence-based and scientifically balanced.

Benoît Trottier, MD has a financial interest/relationship or affiliation in the form of: Consultant: Abbott, Bristol-Myers Squibb, Gilead Sciences, Merck, Janssen, ViiV Healthcare.

Andrew Zolopa, MD has a financial interest/relationship or affiliation in the form of: Research Grant: Gilead Sciences; Consultant: Bristol-Myers Squibb, Gilead Sciences, Janssen. Research Support: VIRxSYS Corporation.

Disclosure of Unlabeled Use
The faculty of this educational activity may include discussions of products that are not currently labeled for use by the FDA. Faculty members have been advised to disclose to the audience any reference to an unlabeled or investigational use. No endorsement of unapproved products or uses is made or implied by coverage of these products or uses. No responsibility is taken for errors or omissions. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings.